Physiologic Frailty and Neurocognitive Decline Among Young-Adult Childhood Cancer Survivors: A Prospective Study From the St Jude Lifetime Cohort.

AnnaLynn M Williams Kevin R KrullCarrie R HowellPia BanerjeeTara M BrinkmanSue C KasteRobyn E Partin Deo Kumar Srivastava Yutaka YasuiGregory T ArmstrongLeslie L Robison Melissa M Hudson Kristen K Ness

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2021)

Over approximately 5 years, prefrail and frail young-adult survivors had greater declines in cognitive domains associated with aging and dementia compared with nonfrail survivors. Interventions that have global impact, designed to target the mechanistic underpinnings of frailty, may also mitigate or prevent neurocognitive decline.

Keyphrases

young adults
community dwelling
childhood cancer
bipolar disorder
mild cognitive impairment
physical activity
cognitive impairment