Low-intensity pulsed ultrasound ameliorates depression-like behaviors in a rat model of chronic unpredictable stress.

Jinniu ZhangHui ZhouJian YangJun JiaLili NiuZuoli SunDandan ShiLong MengWeibao QiuXiaomin WangHairong ZhengGang Wang

Published in: CNS neuroscience & therapeutics (2020)

Chronic LIPUS stimulation can effectively and safely improve depression-like behaviors in CUS rats. The underlying mechanisms may be related to enhancement of BDNF/ERK/mTORC1 signaling pathways in the prefrontal cortex (PFC). LIPUS is a promising noninvasive neuromodulation tool that merits further study as a potential treatment for depression.

Keyphrases

depressive symptoms
prefrontal cortex
signaling pathway
sleep quality
stress induced
magnetic resonance imaging
pi k akt
epithelial mesenchymal transition
computed tomography
oxidative stress
physical activity
combination therapy
contrast enhanced ultrasound