Long COVID: neurological manifestations - an updated narrative review.
José Wagner Leonel Tavares-JúniorGabriella Cunha Vieira CiurleoAlissa Moura FormigaThais de Maria Frota VasconcelosMarcello Holanda de AndradeWerbety Lucas Queiroz FeitosaAntônio Alves Sobreira-NetoChiara Gübel PortugalLorenzo Marinho MoraisSamuel Cavalcante MarinhoEmanuel de Assis Bertulino Martins GomesEsther de Alencar Araripe Falcão FeitosaEmmanuelle Silva Tavares SobreiraReinaldo Barreto OriáManoel Alves Sobreira-NetoPedro Braga NetoPublished in: Dementia & neuropsychologia (2024)
Infection with the SARS-CoV-2 virus can lead to neurological symptoms in the acute phase and in the Long COVID phase. These symptoms usually involve cognition, sleep, smell disorders, psychiatric manifestations, headache and others. This condition is more commonly described in young adults and women. This symptomatology can follow severe or mild cases of the disease. The importance of this issue resides in the high prevalence of neurological symptoms in the Long COVID phase, which entails significant morbidity in this population. In addition, such a condition is associated with high health care costs, with some estimates hovering around 3.7 trillion US dollars. In this review, we will sequentially describe the current knowledge about the most prevalent neurological symptoms in Long COVID, as well as their pathophysiology and possible biomarkers.