Markers of cholesterol synthesis are elevated in adolescents and young adults with type 2 diabetes.
Ivana SemovaAmy E LevensonJoanna KrawczykKevin BullockKathryn A WilliamsR Paul WadwaPhilip R KhouryThomas R KimballElaine M UrbinaSarah D de FerrantiDavid M MaahsLawrence M DolanAmy S ShahClary B ClishSudha B BiddingerPublished in: Pediatric diabetes (2020)
Adolescents and young adults with T2DM show evidence of increased cholesterol synthesis compared to non-diabetic lean controls. These findings suggest that T2DM may promote cardiovascular disease by increasing cholesterol synthesis, and provide additional rationale for the use of cholesterol synthesis inhibitors in this group.