Neuroprotective effect of mitochondrial translocator protein ligand in a mouse model of tauopathy.
Lauren H FairleyNaruhiko SaharaIchio AokiBin JiTetsuya SuharaMakoto HiguchiAnna M BarronPublished in: Journal of neuroinflammation (2021)
These findings support a protective role for TSPO ligands in tauopathy, reducing neuroinflammation, neurodegeneration, and brain atrophy.
Keyphrases
- cerebral ischemia
- mouse model
- subarachnoid hemorrhage
- blood brain barrier
- brain injury
- oxidative stress
- resting state
- protein protein
- white matter
- traumatic brain injury
- lipopolysaccharide induced
- pet imaging
- functional connectivity
- lps induced
- cognitive impairment
- amino acid
- binding protein
- small molecule
- multiple sclerosis
- computed tomography
- inflammatory response
- positron emission tomography