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A novel tubulin inhibitor STK899704 induces tumor regression in DMBA/TPA-induced skin carcinogenesis model.

Joonsung HwangNak Kyun SoungHo Jin HanYongjun LeeTae Woong ChoiJiyun MunHyunjoo Cha-MolstadKyung Ho LeeHyo Joon KimHee Gu LeeJin Tae HongJong Seog AhnYong Tae KwonBo Yeon Kim
Published in: Experimental dermatology (2019)
Skin cancer is the most common type of cancer. The incidence rate of skin cancer has continuously increased over the past decades. In an effort to discover novel anticancer agents, we identified a novel tubulin inhibitor STK899704, which is structurally distinct from other microtubule-binding agents such as colchicine, vinca alkaloids and taxanes. STK899704 inhibited microtubule polymerization leading to mitotic arrest and suppressed the proliferation of various cancer cell lines as well as multidrug resistance cancer cell lines. In this study, our investigation is further extended into animal model to evaluate the effect of STK899704 on skin carcinogenesis in vivo. Surprisingly, almost 80% of the tumors treated with STK899704 were regressed with a one-fifth reduction in tumor volume. Furthermore, the efficacy of STK899704 was nearly 2 times higher than that of 5-fluorouracil, a widely used skin cancer therapeutic. Overall, our results suggest that STK899704 is a promising anticancer chemotherapeutic that may replace existing therapies, particularly for skin cancer.
Keyphrases
  • skin cancer
  • papillary thyroid
  • squamous cell
  • cell cycle
  • lymph node metastasis
  • squamous cell carcinoma
  • signaling pathway
  • wound healing
  • young adults
  • drug induced