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Neuronal CBP-1 is required for enhanced body muscle proteostasis in response to reduced translation downstream of mTOR.

Santina SnowDilawar MirZhengxin MaJordan HorrocksMatthew CoxMarissa RuzgaHussein SayedAric N Rogers
Published in: bioRxiv : the preprint server for biology (2024)
Low translation in either neurons or the germline orchestrate protective adaptation in other tissues, including body muscle.
Keyphrases
  • skeletal muscle
  • gene expression
  • spinal cord
  • cell proliferation
  • dna repair
  • spinal cord injury
  • brain injury
  • blood brain barrier
  • subarachnoid hemorrhage