Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving ALK-Targeted Therapy.

Charles Bobin Yasmine Iddir Charlotte Butterworth Julien Masliah Planchon Alexandra Saint-Charles Angela Bellini Jaydutt Bhalshankar Gaëlle Pierron Valérie Combaret Valerie Attignon Anne Isabelle Bertozzi Nadège Corradini Benoit Dumont Ludovic Mansuy Camille Khanfar Sebastien Klein Claire Briandet Dominique Plantaz Frédéric Millot Sandrine Thouvenin Isabelle Aerts Lee Aymar Ndounga-Diakou Salim Laghouati Samuel D Abbou Nina Jehanno Hubert Tissot Shufang Renault Sylvain Baulande Virginie Raynal Laurence Bozec Ivan Bièche Olivier O Delattre Pablo Berlanga Gudrun Schleiermacher

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

We demonstrate the clinical utility of combining ALK cfDNA ddPCR for disease monitoring and cfDNA WES for the study of clonal evolution and resistance mechanisms in patients with neuroblastoma receiving ALK-targeted therapy.

Keyphrases

advanced non small cell lung cancer