Patterns of abundance, chromosomal localization, and domain organization among c-di-GMP-metabolizing genes revealed by comparative genomics of five alphaproteobacterial orders.
Sonja KoppenhöferAndrew S LangPublished in: BMC genomics (2022)
The observed patterns in the chromosomal localizations of these genes suggest a coupling of synthesis and hydrolysis of c-di-GMP with the cell cycle. Moreover, the higher proportions and diversities of auxiliary domains associated with GGDEF domains and GGDEF-EAL hybrids compared to EAL or HD-GYP domains could indicate that more stimuli affect synthesis compared to hydrolysis of c-di-GMP.
Keyphrases
- biofilm formation
- cell cycle
- pseudomonas aeruginosa
- staphylococcus aureus
- candida albicans
- escherichia coli
- genome wide
- cell proliferation
- copy number
- bioinformatics analysis
- anaerobic digestion
- genome wide identification
- cystic fibrosis
- single cell
- antibiotic resistance genes
- genome wide analysis
- room temperature
- gene expression
- transcription factor