Potent and Selective PTDSS1 Inhibitors Induce Collateral Lethality in Cancers with PTDSS2 Deletion.

Yohei Yoshihama Hidenori Namiki Taiga Kato Naomi Shimazaki Sachiko Takaishi Kumiko Kadoshima-Yamaoka Hideo Yukinaga Naoyuki Maeda Tomoko Shibutani Kazunori Fujimoto Makoto Hirasawa Hiroki Goto Naoya Wada Shinji Tsutsumi Yasuhide Hirota Tomoki Ishikawa Shoji Yamamoto

Published in: Cancer research (2022)

This study identifies a specific dependency on PTDSS1 for phosphatidylserine synthesis following PTDSS2 deletion and introduces novel PTDSS1 inhibitors as a therapeutic option to induce collateral lethality in cancer with PTDSS2 loss.

Keyphrases

papillary thyroid
genome wide
gene expression
dna methylation