Modulation of mTORC1 Signaling Pathway by HIV-1.
Burkitkan AkbayAnna A ShmakovaYegor VassetzkySvetlana DokudovskayaPublished in: Cells (2020)
Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of cellular proliferation and survival which controls cellular response to different stresses, including viral infection. HIV-1 interferes with the mTORC1 pathway at every stage of infection. At the same time, the host cells rely on the mTORC1 pathway and autophagy to fight against virus replication and transmission. In this review, we will provide the most up-to-date picture of the role of the mTORC1 pathway in the HIV-1 life cycle, latency and HIV-related diseases. We will also provide an overview of recent trends in the targeting of the mTORC1 pathway as a promising strategy for HIV-1 eradication.
Keyphrases
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- human immunodeficiency virus
- hepatitis c virus
- signaling pathway
- hiv aids
- men who have sex with men
- induced apoptosis
- south africa
- cell death
- life cycle
- oxidative stress
- transcription factor
- cell proliferation
- drug delivery
- helicobacter pylori
- cell cycle arrest