Estimation of drug receptor occupancy when non-displaceable binding differs between brain regions – extending the simplified reference tissue model.

Matts KågedalKatarina VarnäsAndrew C HookerMats O Karlsson

Published in: British journal of clinical pharmacology (2015)

The extended SRTM allows consideration of white matter as reference region when no suitable grey matter region exists. AZD3783 affinity appears to be higher in the caudate compared with other brain regions.

Keyphrases

white matter
multiple sclerosis
resting state
binding protein
cerebral ischemia
drug induced
adverse drug