Chymase Activity in Plasma and Urine Extracellular Vesicles in Primary Hypertension.
Sarfaraz AhmadGagan DeepHenry A PunziYixin SuSangeeta SinghAshish KumarShalini MishraAmit K SahaKendra N WrightJessica L VonCannonLouis J Dell'ItaliaWayne J MeredithCarlos M FerrarioPublished in: Kidney360 (2024)
These studies reveal a differential enzymatic activity of renin angiotensin system enzymes in plasma and urine EVs isolated from hypertensive patients. Demonstrating a comparatively high chymase enzymatic activity in EVs expands a previously documented finding of increased plasma Ang-(1‒12) in hypertensive patients.