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Muscularis macrophages establish cell-to-cell contacts with telocytes/PDGFRα-positive cells and smooth muscle cells in the human and mouse gastrointestinal tract.

Sihan JiChiara TrainiMagdalini MischopoulouSimon J GibbonsGiovanni LigrestiMaria-Simonetta Faussone-PellegriniLei ShaGianrico FarrugiaMaria Giuliana VannucchiGianluca Cipriani
Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)
This study describes varying patterns of distribution of MMs between different regions of the gut, and reports the presence of distinct and extended cell-to-cell contacts between MMs and smooth muscle cells and between MMs and TCs/PDGFRα-positive cells. In contrast, MMs, although close to ICCs and nerve elements, did not make contact with them. These findings indicate specialized and variable roles for MMs in the modulation of gastrointestinal motility whose significance should be more closely investigated in normal and pathological conditions.
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