Targeted expression profiling reveals distinct stages of early canine fibroblast reprogramming are regulated by 2-oxoglutarate hydroxylases.

Ian C TobiasMian-Mian C KaoThomas ParmentierHailey HunterJonathan LaMarreDean H Betts

Published in: Stem cell research & therapy (2020)

Our findings highlight 2-OG hydroxylases have evolutionarily conserved and divergent functions regulating the early reprogramming of canine somatic cells and show reprogramming conditions can be rationally optimized for the generation of maturing canine iPSC.

Keyphrases

induced apoptosis
cell cycle arrest
transcription factor
gene expression
endoplasmic reticulum stress
oxidative stress
signaling pathway
pi k akt