Soluble guanylate cyclase stimulator reduced the gastrointestinal fibrosis in bleomycin-induced mouse model of systemic sclerosis.

Yuzuru YamamotoTakaichi OkanoHirotaka YamadaKengo AkashiSho SendoYo UedaAkio MorinobuJun Saegusa

Published in: Arthritis research & therapy (2021)

These findings suggest that BLM induces gastrointestinal hyperproliferative and prefibrotic response in C57BL/6J mice, and treatment with sGC stimulator improves the BLM-induced gastrointestinal lesion.

Keyphrases

systemic sclerosis
mouse model
high glucose
interstitial lung disease
diabetic rats
drug induced
type diabetes
oxidative stress
adipose tissue
pulmonary fibrosis
idiopathic pulmonary fibrosis