Association of Age at Onset With Gray Matter Volume and White Matter Microstructural Abnormalities in People With Multiple Sclerosis.
Raffaello BonacchiAlessandro MeaniElisabetta PaganiOlga MarchesiAndrea FaliniMassimo FilippiMaria Assunta RoccaPublished in: Neurology (2021)
Younger patients are initially resilient to MS-related damage. Then, compensatory mechanisms start failing with loss of WM integrity, followed by GM atrophy and finally disability.