HER2 mRNA transcript quantitation in breast cancer.

Katie L MeehanB ClynickB MirzaiP MaslenJ M HarveyW N Erber

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2016)

ddPCR can be used to quantify HER2 mRNA transcripts in FFPE breast cancer specimens. Our results highlight the potential of ddPCR on FFPE tissue to be used to accurately quantify HER2 transcripts. Validation in large cohorts will be required to determine a clinically applicable cutoff.

Keyphrases

mass spectrometry
ms ms
rna seq
high resolution
tandem mass spectrometry