Depletion of acetate-producing bacteria from the gut microbiota facilitates cognitive impairment through the gut-brain neural mechanism in diabetic mice.
Hong ZhengPengtao XuQiaoying JiangQingqing XuYafei ZhengJunjie YanHui JiJie NingXi ZhangChen LiLimin ZhangYuping LiXiaokun LiWeihong SongHong-Chang GaoPublished in: Microbiome (2021)
Our results demonstrate the protective role of microbiota metabolite acetate in cognitive functions and suggest long-term acetate deficiency as a risk factor of cognitive decline. Video Abstract.