A Case Report of a Severe, Unusually Delayed Anaphylactoid Reaction to Intravenous N-Acetylcysteine During Treatment of Acute Acetaminophen Toxicity in an Adolescent.
L Claire EppersonStephanie T WeissDazhe James CaoPublished in: Journal of medical toxicology : official journal of the American College of Medical Toxicology (2020)
Discontinuing NAC in this case of severe, delayed anaphylactoid reaction could have resulted in FHF requiring liver transplant. The reason for her reaction is unclear but could be related to patient risk factors or medication error. Guidelines for reinitiation of NAC after development of delayed anaphylactoid reactions are not well-established. Close observation beyond the first 1-5 hours of NAC administration is warranted.
Keyphrases
- transcription factor
- drug induced
- risk factors
- liver injury
- early onset
- liver failure
- young adults
- healthcare
- genome wide analysis
- mental health
- oxidative stress
- electron transfer
- clinical practice
- case report
- respiratory failure
- emergency department
- intensive care unit
- aortic dissection
- hepatitis b virus
- electronic health record
- acute respiratory distress syndrome