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New composition of tungsten has a broad range of antiviral activity.

Hranush AvagyanAnaida MirzoyanFerdinand MirzoyanRoza IzmailyanSona HakobyanHenry VoskanyanZara SemerjyanAida AvetisyanHranush ArzumanyanElena KaralovaLiana AbroyanLina HakobyanNane BayramyanNazeli GevorgyanAlexander KaralyanZaven A Karalyan
Published in: Antiviral chemistry & chemotherapy (2022)
The water-based combination of two inorganic chemical compounds such as sodium tungstate dihydrate-Na 2 WO 4  × 2H 2 O and Aluminum sulfate octadecahydrate-Al 2 (SO 4 ) 3 × 18H 2 O that we have conditionally named 'Vomifal' has a broad antiviral activity in various DNA and RNA viruses, including Human Herpes Virus (HHV), African Swine Fever Virus (ASFV), Vaccinia Virus (VV), Hepatitis C Virus (HCV), Foot and Mouth Disease Virus (FMDV), Influenza A virus (A/Aichi/2/68 (H3N2)). In vitro and In vivo assays in several tissue cultures as well as in laboratory animals, conformed 'Vomifal' has a very low toxicity and the antiviral properties partially are due to its ability to induce gamma-IFN. Based on the results obtained, we can assume the presence of at least two mechanisms of the antiviral action of the studied drug. First or early stage - an unknown mechanism, possibly related to the effect on cellular receptors. Second or late stage - main antiviral properties probably associated with an interferonogenic effect.
Keyphrases
  • hepatitis c virus
  • early stage
  • disease virus
  • human immunodeficiency virus
  • immune response
  • high throughput
  • dendritic cells
  • radiation therapy
  • cell free
  • adverse drug
  • locally advanced
  • neoadjuvant chemotherapy