Comparative transcriptomic analysis of antimony resistant and susceptible Leishmania infantum lines.

Juvana Moreira AndradeLeilane Oliveira GonçalvesDaniel Barbosa LiarteDavi Alvarenga LimaFrederico Gonçalves GuimarãesDaniela de Melo ResendeAna Maria Murta SantiLuciana Marcia de OliveiraJoão Paulo Linhares VellosoRenato Guimarães DelfinoPascale PescherGerald F SpäthJeronimo Conceição RuizSilvane Maria Fonseca Murta

Published in: Parasites & vectors (2020)

The transcriptomic profile of L. infantum showed a robust set of genes from different metabolic pathways associated with the antimony resistance phenotype in this parasite. Our results address the complex and multifactorial antimony resistance mechanisms in Leishmania, identifying several candidate genes that may be further evaluated as molecular targets for chemotherapy of leishmaniasis.

Keyphrases

genome wide
single cell
locally advanced
rna seq
radiation therapy
gene expression
squamous cell carcinoma
single molecule
life cycle