Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging.
Jiang OuyangAngel XieJun ZhouRuncong LiuLiqiang WangHaijun LiuNa KongWei TaoPublished in: Chemical Society reviews (2022)
Traditional treatments such as chemotherapy and surgery usually cause severe side effects and excruciating pain. The emergence of nanomedicines and minimally invasive therapies (MITs) has brought hope to patients with malignant diseases. Especially, minimally invasive nanomedicines (MINs), which combine the advantages of nanomedicines and MITs, can effectively target pathological cells/tissues/organs to improve the bioavailability of drugs, minimize side effects and achieve painless treatment with a small incision or no incision, thereby acquiring good therapeutic effects. In this review, we provide a comprehensive review of the research status and challenges of MINs, which generally refers to the medical applications of nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging. Additionally, we also discuss their combined application in various fields including cancers, cardiovascular diseases, tissue engineering, neuro-functional diseases, and infectious diseases. The prospects, and potential bench-to-bedside translation of MINs are also presented in this review. We expect that this review can inspire the broad interest for a wide range of readers working in the fields of interdisciplinary subjects including (but not limited to) chemistry, nanomedicine, bioengineering, nanotechnology, materials science, pharmacology, and biomedicine.
Keyphrases
- minimally invasive
- infectious diseases
- tissue engineering
- high resolution
- cardiovascular disease
- magnetic resonance imaging
- robot assisted
- chronic pain
- healthcare
- gene expression
- induced apoptosis
- stem cells
- public health
- spinal cord
- squamous cell carcinoma
- cell cycle arrest
- type diabetes
- neuropathic pain
- metabolic syndrome
- replacement therapy
- mesenchymal stem cells
- pain management
- coronary artery disease
- combination therapy
- coronary artery bypass
- cell therapy
- photodynamic therapy
- locally advanced
- cardiovascular events
- bone marrow
- postoperative pain