Somatic Mutations and Clonal Hematopoiesis as Drivers of Age-Related Cardiovascular Risk.
Bernhard HaringStephanie WisselJoAnn E MansonPublished in: Current cardiology reports (2022)
CHIP has been associated with accelerated atherosclerosis and cardiovascular disease in both epidemiological and experimental studies. The most commonly mutated candidate driver genes are DNMT3A, TET2, JAK2, and ASXL1. The underlying mechanisms appear predominantly related to inflammatory pathways. Although age is the dominant risk factor for developing CHIP, emerging evidence suggests that other factors such as smoking, obesity/type 2 diabetes, or an unhealthy diet play a role in the occurrence of somatic mutations. Evidence suggests a strong link between vascular risk factors, somatic hematopoietic mutations, and age-related cardiovascular disease. Further studies on CHIP biology are required to identify targeted interventions for risk reduction in patients with CHIP and inform the utility of screening strategies.
Keyphrases
- cardiovascular disease
- type diabetes
- high throughput
- circulating tumor cells
- risk factors
- copy number
- weight loss
- insulin resistance
- case control
- metabolic syndrome
- cardiovascular risk factors
- risk assessment
- bone marrow
- cardiovascular events
- dna methylation
- genome wide
- glycemic control
- oxidative stress
- adipose tissue
- single cell
- gene expression
- transcription factor
- drug delivery
- body mass index