Targeting VEGF-A/VEGFR2 Y949 Signaling-Mediated Vascular Permeability Alleviates Hypoxic Pulmonary Hypertension.

Weibin ZhouKeli LiuLei ZengJiaqi HeXinbo GaoXinyu GuXun ChenJing Jing LiMinghui WangDuoguang WuZhixiong CaiLena Claesson-WelshRong JuJingfeng WangFeng Zhang Yang-Xin Chen

Published in: Circulation (2022)

Our results support the notion that VEGF-A/VEGFR2 Y949-dependent vascular permeability is an important determinant in the pathogenesis of PH and might serve as an attractive therapeutic target pathway for this disease.

Keyphrases

vascular endothelial growth factor
endothelial cells
pulmonary hypertension
pulmonary artery
pulmonary arterial hypertension
cancer therapy
mouse model
coronary artery