Reductive stress imaging in the endoplasmic reticulum by using living cells and zebrafish.
Huawei NiuYongru ZhangFangfang ZhaoSaijun MoWenbo CaoYong YeYufen ZhaoPublished in: Chemical communications (Cambridge, England) (2019)
Excessive accumulation of reducing agents in the ER leads to a constitutively high UPR. And the co-function of GSH, Cys and HOCl in biological processes is not well understood. To address this, a TP probe, NPCC, was developed for monitoring reductive stress in the ER. It can also distinguish cancer cells from normal cells.
Keyphrases
- endoplasmic reticulum
- living cells
- fluorescent probe
- induced apoptosis
- single molecule
- papillary thyroid
- cell cycle arrest
- high resolution
- squamous cell
- weight gain
- cell death
- estrogen receptor
- physical activity
- endoplasmic reticulum stress
- mass spectrometry
- signaling pathway
- lymph node metastasis
- heat stress
- fluorescence imaging