The presence and distribution of various genes in postnatal CLP-affected palatine tissue.

Published in: Maxillofacial plastic and reconstructive surgery (2024)

Changes in the cleft-affected palatine epithelium primarily seem to be associated with the PAX7 gene; however, PAX9, WNT3A, WNT9B, and SOX3 role seems to be more limited. Whilst connective tissue changes seem to depend on PAX7 only, SHH seems to participate individually and indistinctly. Numerous positive correlations reflect the complicating interactions of the pathways and their components in the orofacial cleft morphopathogenesis.

Keyphrases

stem cells
genome wide
cell proliferation
genome wide identification
transcription factor
preterm infants
copy number
gene expression
bioinformatics analysis