Acid-sensing ion channel 3 blockade inhibits durovascular and nitric oxide-mediated trigeminal pain.

Christopher M HoltonLauren C StrotherIsaac DrippsAmynah Amir Ali PradhanPeter J GoadsbyPhilip Robert Holland

Published in: British journal of pharmacology (2020)

These results support the development of specific ASIC3 or combined ASIC1/3 blockers for migraine-related pain and point to a potential role for ASIC-dependent NO-mediated attack triggering. This has key implications for migraine, given the major unmet need for novel therapeutic targets.

Keyphrases

neuropathic pain
chronic pain
nitric oxide
pain management
spinal cord
spinal cord injury
hydrogen peroxide