Biological potential alterations of migratory chondrogenic progenitor cells during knee osteoarthritic progression.

Yu-Xing WangZhi-Dong ZhaoQian WangZhong-Li LiYa HuangSen ZhaoWei HuJia-Wu LiangPei-Lin LiHua WangNing MaoChu-Tse WuHeng Zhu

Published in: Arthritis research & therapy (2020)

Our data suggest that more mCPCs (grades 3-4) migrate to injured articular cartilages but with enhanced osteo-adipogenic and decreased chondrogenic capacity, which might explain the pathological changes of mCPCs during the progression of OA from early to late stages. Thus, these dysfunctional mCPCs might be optional cell targets for OA therapies.

Keyphrases

knee osteoarthritis
mesenchymal stem cells
total knee arthroplasty
single cell
cell therapy
big data
stem cells
human health
deep learning