Clerodane Diterpenoids from an Edible Plant Justicia insularis: Discovery, Cytotoxicity, and Apoptosis Induction in Human Ovarian Cancer Cells.

Idowu E FadayomiOkiemute R Johnson-AjinwoElisabete PiresJames McCullaghTim D W ClaridgeNicholas Robert Forsyth Wen-Wu Li

Published in: Molecules (Basel, Switzerland) (2021)

Clerodane diterpenoids (1 and 2) in J. insularis were identified as cytotoxic to ovarian cancer cells via the induction of apoptosis, providing an abundant and valuable source of hit compounds for the treatment of ovarian cancer.

Keyphrases

endoplasmic reticulum stress
cell cycle arrest
oxidative stress
cell death
endothelial cells
small molecule
induced pluripotent stem cells
high throughput
pi k akt
cell proliferation
signaling pathway
replacement therapy
anti inflammatory