Efficacy of EZH2 inhibitory drugs in human papillomavirus-positive and human papillomavirus-negative oropharyngeal squamous cell carcinomas.

Cameron D LindsayMorris A KostiukJeff HarrisDaniel A O'ConnellHadi SeikalyVincent L Biron

Published in: Clinical epigenetics (2017)

Our findings suggest that EZH2 inhibitors are a viable therapeutic option for the role of epigenetic effect, potentially sensitizing tumors to current chemotherapies or limiting cell differentiation.

Keyphrases

squamous cell
long noncoding rna
long non coding rna
dna methylation
gene expression
high grade
drug induced