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Phenotypic characterization of testicular immune cells expressing immune checkpoint molecules in wild-type and pituitary adenylate cyclase-activating polypeptide-deficient mice.

Matyas MeggyesAdrienn LajkoBalazs Daniel FulopDora ReglodiLaszlo Szereday
Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2019)
We hypothesize that these local changes may result in an immune activation with disturbed testicular immunoregulation in PACAP KO mice; however, determining the exact function requires further investigations. Our data further support the view that besides a systemic immune tolerance, localized active immunosuppression is involved in the regulation of testicular immune privilege.
Keyphrases
  • wild type
  • germ cell
  • signaling pathway
  • electronic health record
  • density functional theory
  • high fat diet induced
  • skeletal muscle
  • adipose tissue
  • insulin resistance
  • data analysis