Consequences of Using Post- or Pre-Bronchodilator Reference Values in Interpreting Spirometry.
Andrei MalinovschiXingwu ZhouAnders AnderssonHelena BackmanBjörn BakeAnders BlombergKenneth CaidahlMaria J ErikssonJonas Eriksson StrömViktor HamreforsOla HjelmgrenChrister JansonReza KarimiDavid KylhammarAnne LindbergEva LindbergPer LivAnna-Carin OlinAdel ShalabiC Magnus SköldJohan SundströmHanan TanashKjell TorénPer WollmerSuneela ZaighamCarl Johan ÖstgrenJan E EngvallPublished in: American journal of respiratory and critical care medicine (2023)
Pre- and post-bronchodilator spirometry reference values differ with regard to FEV1/FVC ratio. Use of post-bronchodilator reference values doubled the population prevalence of airflow obstruction; this was related to a higher respiratory burden. Using post-bronchodilator reference values when interpreting post-bronchodilator spirometry might enable identification of individuals with mild disease and be clinically relevant.