Herbal formula Huangqi Guizhi Wuwu decoction attenuates paclitaxel-related neurotoxicity via inhibition of inflammation and oxidative stress.
Zhangming LvJiayun ShenXuejiao GaoYonglan RuanJinying LingRongwei SunJingya DaiHaizhen FanXiaolan ChengPeng CaoPublished in: Chinese medicine (2021)
These combined data showed that HGWD could inhibit paclitaxel-evoked inflammatory and oxidative responses in peripheral nervous system viaTLR4/NF-κB and PI3K/Akt-Nrf2 pathways involvement. The neuroprotective property of HGWD on PIPN provides fundamental support to the potential application of HGWD for counteracting the side effects of paclitaxel during chemotherapy.
Keyphrases
- oxidative stress
- pi k akt
- chemotherapy induced
- signaling pathway
- cell cycle arrest
- cell proliferation
- diabetic rats
- induced apoptosis
- ischemia reperfusion injury
- dna damage
- electronic health record
- big data
- cell death
- cerebral ischemia
- preterm infants
- human health
- brain injury
- heat stress
- inflammatory response
- climate change
- machine learning