Combined cortisol and melatonin measurements with detailed parameter analysis can assess the circadian rhythms in bipolar disorder patients.
Liang FangQuanmei YuFanfan YinJiakuai YuYunfei ZhangYu ZhangDaomin ZhuXiming QinPublished in: Brain and behavior (2021)
With detailed parameter analysis, the combined detection of melatonin and cortisol can better judge the biological clock disorder of bipolar patients. The circadian rhythms of patients at the recovery stage tend to be normal. The clock gene expression examination needs strict quality control and more investigations before being applied to assess human circadian rhythms.
Keyphrases
- bipolar disorder
- gene expression
- quality control
- end stage renal disease
- endothelial cells
- ejection fraction
- dna methylation
- chronic kidney disease
- major depressive disorder
- prognostic factors
- peritoneal dialysis
- sensitive detection
- induced pluripotent stem cells
- real time pcr
- loop mediated isothermal amplification