CAR-T Cell-Mediated B-Cell Depletion in Central Nervous System Autoimmunity.

Sasha GuptaMilos SimicSharon A SaganChanelle ShepherdJason DueckerRaymond A SobelRavi DandekarGregory F WuWesley WuJohn E PakStephen L HauserWendell LimMichael R WilsonScott S Zamvil

Published in: Neurology(R) neuroimmunology & neuroinflammation (2023)

In contrast to previous data showing that anti-CD19 CAR-T cell treatment exacerbated EAE, we observed that anti-CD19 CAR-T cells ameliorated EAE. In addition, anti-CD19 CAR-T cells thoroughly depleted B cells in peripheral tissues and in the CNS. However, the clinical benefit occurred independently of antigen specificity or B-cell depletion.

Keyphrases

single cell
cell therapy
nk cells
magnetic resonance
gene expression
blood brain barrier
electronic health record
magnetic resonance imaging
computed tomography
big data
deep learning
bone marrow
smoking cessation