Hyaluronic acid and proliferation/cellular death amount in the female rats mammary gland after estroprogestative therapy.
Sueli M P S TorresHelena B NaderRicardo Dos Santos SimõesEdmund Chada BaracatJosé Maria Soares JúniorManuel de J SimõesRegina C T GomesPublished in: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (2021)
Our results suggest that the excessive reduction of HA in mammary tissue, as occurred with progesterone treatment, can lead to a breakdown of the extracellular matrix. These changes may be indicative of mammary pathology such as the development of tumor.