S100A8/A9-activated IFNγ + NK cells trigger β-cell necroptosis in hepatitis B virus-associated liver cirrhosis.

Xuehui LiLiang HongMingHui RuRui CaiYuting MengBaohua WangHongyan DiaoLanjuan LiZhongwen Wu

Published in: Cellular and molecular life sciences : CMLS (2024)

Together, the data indicate that IFN-γ produced by NK cells induces β cell necroptosis via the S100A8/A9-RAGE-p38 MAPK axis in patients with LC and DM. Reduced levels of S100A8/A9, NK cells, and IFN-γ could be valuable for the treatment of LC with DM. Accumulation of S100A8/A9 in patients with LC may indicate the emergence of DM.

Keyphrases

nk cells
hepatitis b virus
dendritic cells
immune response
single cell
simultaneous determination
cell therapy
mass spectrometry
liver failure
type diabetes
stem cells
electronic health record
metabolic syndrome
combination therapy
bone marrow
solid phase extraction