Amide to Alkyne Interconversion via a Nickel/Copper-Catalyzed Deamidative Cross-Coupling of Aryl and Alkenyl Amides.

Watchara SrimontreeAdisak ChatupheeraphatHsuan-Hung LiaoMagnus Rueping

Published in: Organic letters (2017)

A nickel-catalyzed deamidative cross-coupling reaction of amides with terminal alkynes as coupling partners was disclosed. This newly developed methodology allows the direct interconversion of amides to alkynes and enables a facile route for C(sp2)-C(sp) bond formation in a straightforward and mild fashion.

Keyphrases

reduced graphene oxide
room temperature
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oxide nanoparticles
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electron transfer
gold nanoparticles
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transition metal