Circulating anti-nuclear autoantibodies in COVID-19 survivors predict long-COVID symptoms.
Kiho SonRameen JamilAbhiroop ChowdhuryManan MukherjeeCarmen VenegasKate MiyasakiKayla ZhangZil PatelBrittany SalterAgnes Che Yan YuenKevin Soon-Keen LauBraeden CowbroughKatherine RadfordChynna HuangMelanie KjarsgaardAnna Dvorkin-GhevaJames SmithQuan-Zhen LiSusan WasermanChristopher J RyersonParameswaran NairTerence N HoNarayanaswamy BalakrishnanIshac NazyDawn M E BowdishSarah SvenningsenChristopher CarlstenManali MukherjeePublished in: The European respiratory journal (2022)
Persistently positive ANAs at 12 months post-COVID are associated with persisting symptoms and inflammation (TNFα) in a subset of COVID-19 survivors. This finding indicates the need for further investigation into the role of autoimmunity in PASC.