Cysteine-responsive prodrug of the anti-cancer drug amonafide: fluorogenic adjuvant drug delivery with hydrogen sulfide (H 2 S).

Sulendar K Mahato Pallavi Barman Md Badirujjaman Krishna Pada Bhabak

Published in: Chemical communications (Cambridge, England) (2023)

L-Cysteine (Cys)-responsive turn-on fluorogenic prodrug AM-ITC was developed for the adjuvant delivery of the anti-cancer drug amonafide and the gasotransmitter hydrogen sulfide (H 2 S) in aqueous and cellular media. Considering the cytoprotective roles of H 2 S, the present adjuvant strategy would be helpful in minimizing the anti-cancer drug-induced side-effects.

Keyphrases

drug induced
cancer therapy
liver injury
drug delivery
early stage
fluorescent probe
living cells
adverse drug
drug release
ionic liquid
single molecule