The Role of Viral Infections in the Onset of Autoimmune Diseases.
Bhargavi SundaresanFatemeh ShirafkanKevin RippergerKristin RattayPublished in: Viruses (2023)
Autoimmune diseases (AIDs) are the consequence of a breach in immune tolerance, leading to the inability to sufficiently differentiate between self and non-self. Immune reactions that are targeted towards self-antigens can ultimately lead to the destruction of the host's cells and the development of autoimmune diseases. Although autoimmune disorders are comparatively rare, the worldwide incidence and prevalence is increasing, and they have major adverse implications for mortality and morbidity. Genetic and environmental factors are thought to be the major factors contributing to the development of autoimmunity. Viral infections are one of the environmental triggers that can lead to autoimmunity. Current research suggests that several mechanisms, such as molecular mimicry, epitope spreading, and bystander activation, can cause viral-induced autoimmunity. Here we describe the latest insights into the pathomechanisms of viral-induced autoimmune diseases and discuss recent findings on COVID-19 infections and the development of AIDs.
Keyphrases
- sars cov
- risk factors
- high glucose
- diabetic rats
- drug induced
- induced apoptosis
- antiretroviral therapy
- multiple sclerosis
- cardiovascular events
- emergency department
- oxidative stress
- genome wide
- cell cycle arrest
- climate change
- cell proliferation
- copy number
- dna methylation
- single molecule
- immune response
- adverse drug
- pi k akt