Screening of anti-thrombin active components from Ligusticum chuanxiong by affinity-ultrafiltration coupled with HPLC-Q-Orbitrap-MS n .
Chencun HuangYuan ZhaoShiyi HuangLi LiZhiying YuanGuangming XuPublished in: Phytochemical analysis : PCA (2023)
The present study revealed that chuanxiong is a traditional Chinese medicine with excellent anticoagulation effects. Meanwhile, the integrated strategy based on AUF-MS, in vitro experiments and molecular docking also provided a powerful tool for further exploration of active ingredients responsible for the anticoagulant activity in chuanxiong.
Keyphrases
- molecular docking
- mass spectrometry
- ms ms
- venous thromboembolism
- atrial fibrillation
- multiple sclerosis
- molecular dynamics simulations
- liquid chromatography
- high performance liquid chromatography
- capillary electrophoresis
- high resolution
- simultaneous determination
- gas chromatography
- single cell
- solid phase extraction