Disruptions in antigen processing and presentation machinery on sarcoma.
Salvatore Lorenzo RenneLaura Sama'Sonia KumarOmer MintemurLaura RuspiIlaria SantoriFederico SicoliAlexia BertuzziAlice LaffiArturo BonomettiPiergiuseppe ColomboVittoria D'amatoAlessandra BressanMarta ScorsettiLuigi TerraccianoPierina NavarriaMaurizio D'incalciVittorio QuagliuoloFabio PasqualiniFabio GrizziFerdinando Carlo Maria CananziPublished in: Cancer immunology, immunotherapy : CII (2024)
Sarcomas exhibit a high degree of defects in APM components, with differences among histotypes and tumoral areas. The most commonly altered APM components were HLA Class I subunit β2-microglobulin, HLA Class I subunit α (HC10), and MHC I transporting unit TAP2. The loss of APM components was prognostic of DM and OS and clinically relevant for LMS and DDLPS. This study explores sarcoma molecular mechanisms, enriching personalized therapeutic approaches.