Antipsychotics in routine treatment are minor contributors to QT prolongation compared to genetics and age.

Leif HommersMaike Scherf-ClavelRoberta StempelJulian RothMatthias FalterJürgen DeckertManuel MattheisenStefan UntereckerMicha Gawlik

Published in: Journal of psychopharmacology (Oxford, England) (2021)

Individual genetic factors and age are main determinants of the QT interval. Antipsychotic drug serum concentrations within the therapeutic range contribute to QTc prolongation on an individual level.

Keyphrases

drug induced
genome wide
adverse drug
clinical practice
copy number
gene expression
emergency department
dna methylation
combination therapy
replacement therapy