Current perspectives on tractography-guided deep brain stimulation for the treatment of mood disorders.
Jason L ChanAriane V CarpentierErik H MiddlebrooksMichael S OkunJoshua K WongPublished in: Expert review of neurotherapeutics (2023)
Tractography-guided DBS is a promising tool for improving DBS outcomes for mood disorders. Tractography is particularly useful for targeting patient-specific white matter tracts that are not visible using conventional structural MRI. Developments in tractography methods will help refine DBS targeting for TRD and may facilitate symptom-specific precision neuromodulation. Ultimately, the standardization of tractography methods will be essential to transforming DBS into an established therapy for mood disorders.
Keyphrases
- deep brain stimulation
- white matter
- parkinson disease
- obsessive compulsive disorder
- multiple sclerosis
- bipolar disorder
- sleep quality
- magnetic resonance imaging
- cancer therapy
- type diabetes
- physical activity
- computed tomography
- skeletal muscle
- adipose tissue
- depressive symptoms
- contrast enhanced
- insulin resistance
- combination therapy
- drug delivery
- weight loss
- glycemic control
- replacement therapy
- diffusion weighted imaging