Mechanisms of artemether toxicity on single cardiomyocytes and protective effect of nanoencapsulation.

Ana Carolina Moreira Souza Francisco F DE Lima Neto Jader Dos Santos Cruz Artur Santos-Miranda Charlotte Farah Liliam Teixeira Oliveira Alexandre Lucas Franck Aimond Pierre Sicard Vanessa Carla Furtado Mosqueira Sylvain Richard

Published in: British journal of pharmacology (2020)

Artemether induced NCX-dependent AP lengthening (explaining QTc prolongation) and disrupted Ca2+ handling, both effects increasing pro-arrhythmogenic risks. NCs prevented these adverse effects, providing a safe alternative to the use of artemether alone, especially to treat malaria.

Keyphrases

high glucose
drug induced
diabetic rats
oxidative stress
transcription factor
endothelial cells
human health
resting state
functional connectivity