Point-by-Point Pulsed Field Ablation Using a Multimodality Generator and a Contact Force-Sensing Ablation Catheter: Comparison With Radiofrequency Ablation in a Remapped Chronic Swine Heart.
Luigi Di BiaseJacopo MarazzatoFengwei ZouAung LinVito GrupposoNilarun ChowdhuriJennifer MaffreSalman Farshchi-HeydariTushar SharmaChristopher BeecklerAssaf GovariRahul BhardwajSanghamitra MohantySanghamitra MohantyHiroshi NakagawaXiao-Dong ZhangPublished in: Circulation. Arrhythmia and electrophysiology (2023)
In a randomized preclinical study, focally delivered unipolar/biphasic PFA guided by contact force values was associated with durable lesions on chronic remapping and with mature scar formation on histology without signs of collateral injury on necroscopy. Further studies are needed to investigate the long-term feasibility of this new approach to atrial fibrillation treatment.
Keyphrases
- radiofrequency ablation
- atrial fibrillation
- catheter ablation
- single molecule
- heart failure
- left atrial
- stem cells
- left atrial appendage
- percutaneous coronary intervention
- drug induced
- oral anticoagulants
- combination therapy
- coronary artery disease
- ultrasound guided
- acute coronary syndrome
- mesenchymal stem cells
- wound healing