Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours.

Silpa GampalaFenil ShahChi ZhangSteven D RhodesOlivia BabbMichelle GrimardRandall S WiremanEllie RadBrian CalverRen-Yuan BaiVerena StaedtkeEmily L HulseyM Reza SaadatzadehKaren E PollokYan TongAbbi E SmithD Wade ClappAndrew R TeeMark R KelleyMelissa L Fishel

Published in: British journal of cancer (2021)

Our findings implicate a unique therapeutic approach to target important MPNST signalling nodes in sarcomas using new first-in-class small molecules for potential translation to the clinic.

Keyphrases

peripheral nerve
transcription factor
primary care
sentinel lymph node
gene expression
cell proliferation
high grade
human health
heat shock
oxidative stress
risk assessment
heat stress