Unmasking hidden risks: The surprising link between PDE5 inhibitors and seizure susceptibility.
Alex Luiz Menezes da SilvaChirlene Pinheiro NascimentoJulianne Elba Cunha AzevedoLuana Rodrigues VieiraAkira Otake HamoyAllan Carlos da Silva TiagoJoão Cleiton Martins RodriguesDaniella Bastos de AraujoDielly Catrina Favacho LopesVanessa Jóia de MelloMoisés HamoyPublished in: PloS one (2023)
PDE5i altered the ECoG recordings in the rats' motor cortexes, demonstrating cerebral asynchrony and potentiating the action of PTZ. These findings demonstrate that PDE5i can lower the seizure threshold.